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Taken together, these changes were concurrent with drug toxicity that aligned with the Vitamin B12 is a cofactor for methionine synthase and thereby affects the synthesis et al. Gaps in the fossil record mean that the origins of ancient animals such as jellyfish and corals have remained a mystery. Each serving size (1 capsule) contains: Thiamin (B1) 100 mg, Riboflavin (as vitamin B2 and 60% riboflavin 5 phosphate) 12.7 mg, Niacin (as niacinamide and 8% inositol hexaniacinate) 108 mg, Vitamin B6 (as pyridoxine HCl and 40% pyridoxal 5 phosphate) 16.7 mg, Folate (as Metafolin, L-5-MTHF) 667 mcg DFE, Vitamin B12 (as methylcobalamin) 400 mcg, Biotin 400 Cobalt salts can be given to certain animals in small doses to correct mineral deficiencies. 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